Dr. John Campbell is an internet sensation, giving facts & data to help us navigate healthcare in the present day. The interview covers John’s development, work, rise to fame & what he would do to help get healthcare back in shape.
RNA vaccines are efficient preventive measures to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7–18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9–2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.
The surge in Strep A cases killing schoolchildren is linked to lockdown, health officials have admitted for the first time.
It comes as the tally of primary-school-aged children to die from the bacterial infection climbed to seven following the death of a child at Morelands Primary in Waterlooville, Hampshire.
‘We’d been quite careful for most of the pandemic, wearing masks and avoiding many big events. But I was pretty confident that, if I did get it, I would be fine because I’d had my jabs. But I couldn’t get out of bed for days and it took almost a month for me to fully recover.’
The COVID-19 pandemic has led people to wear face masks daily in public. Although the effectiveness of face masks against viral transmission has been extensively studied, there have been few reports on potential hygiene issues due to bacteria and fungi attached to the face masks. We aimed to (1) quantify and identify the bacteria and fungi attaching to the masks, and (2) investigate whether the mask-attached microbes could be associated with the types and usage of the masks and individual lifestyles. We surveyed 109 volunteers on their mask usage and lifestyles, and cultured bacteria and fungi from either the face-side or outer-side of their masks. The bacterial colony numbers were greater on the face-side than the outer-side; the fungal colony numbers were fewer on the face-side than the outer-side. A longer mask usage significantly increased the fungal colony numbers but not the bacterial colony numbers. Although most identified microbes were non-pathogenic in humans; Staphylococcus epidermidis, Staphylococcus aureus, and Cladosporium, we found several pathogenic microbes; Bacillus cereus, Staphylococcus saprophyticus, Aspergillus, and Microsporum. We also found no associations of mask-attached microbes with the transportation methods or gargling. We propose that immunocompromised people should avoid repeated use of masks to prevent microbial infection.
“We’re facing a multidemic of respiratory viruses, there’s three or four of them causing trouble … influenza, RSV, para-influenza, adenovirus, HMPV, there are a lot,” Mr Booy said.
“Winter naturally leads to perspiration, indoor crowding and lack of adequate ventilation.
“Because were locked down for two years, the level of natural immunity dropped off against flu and Covid, so we happen to have a lot of cases and deaths due to Omicron and the opening of a society with less natural immunity.
RESULTS Of 1050 eligible HCW, 154 and 120 were enrolled to receive BNT162b2 and mRNA1273, respectively, and compared to 426 age-matched controls. Recipients of both vaccine types had a ∼9-10-fold increase in IgG and neutralizing titers within 2 weeks of vaccination and an 8-fold increase in live Omicron VOC neutralization, restoring titers to those measured after the third vaccine dose. Breakthrough infections were common, mostly very mild, yet, with high viral loads. Vaccine efficacy against infection was 30% (95%CI:-9% to 55%) and 11% (95%CI:-43% to +43%) for BNT162b2 and mRNA1273, respectively. Local and systemic adverse reactions were reported in 80% and 40%, respectively.
CONCLUSIONS The fourth COVID-19 mRNA dose restores antibody titers to peak post-third dose titers. Low efficacy in preventing mild or asymptomatic Omicron infections and the infectious potential of breakthrough cases raise the urgency of next generation vaccine development.
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
People with high levels of T cells from common colds are less likely to catch COVID, according to a new peer-reviewed study.
Researchers said the findings could help provide the blueprint for the production of new vaccines which give longer-lasting immunity and would protect against current and future coronavirus variants such as Omicron and Delta.
More than thirty doctors, scientists and MP’s have signed a joint letter to the government’s vaccine watchdog urging it to “reassess” the Covid vaccine rollout for healthy 12-15 year olds following new data showing potentially serious harms of the jab are likely to outweigh any potential benefits.
It argues the risk benefit calculations made by the JCVI and the Chief Medical Officer were based on “less than complete data on both the harms and the benefits of vaccinating children compared to the evidence now available.”
It cites new evidence showing the risk of myocarditis in young men and boys is up to 14 times higher after vaccination than after infection.
And it states that given the high level of naturally acquired immunity from infection as well as the replacement of the Delta variant by milder Omicron, “it’s crucial that, if we are to proceed with the mass double vaccination of healthy children, we are absolutely certain this policy will do more good than harm.”
It states that the justification for vaccinating children was to provide “marginal benefits” of reducing time spent out of school due to covid infection but it cites new data showing that vaccines are no longer effective at preventing infection with Omicron.
It states: “Furthermore, the negligible risks of Covid infection to children have become even more nugatory if, as it appears, Omicron is associated with less severe disease, whereas the benefits of natural infection (rather than vaccination) in terms of longer lasting immunity are becoming more clear.”
The Covid modellers at Imperial College have begun to back down. About time too. Over the past few weeks, they have made extreme claims about the omicron variant that cannot be fully justified by fundamental science, let alone by clinical observation.
Dr. Peter A. McCullough, MD, MPH, is a board-certified cardiologist who has testified before committees of the US and Texas Senate regarding the treatment of COVID-19 and management of the ongoing pandemic.
These data suggest that virtually all individuals with existing anti-SARS-CoV-2 CD8+ T-cell responses should recognize the Omicron VOC, and that SARS-CoV-2 has not evolved extensive T-cell escape mutations at this time.
Scientists believe they have solved the mystery behind the extremely rare blood clots caused by the Oxford-AstraZeneca vaccine.
A team of international experts, involving researchers from AstraZeneca, say that in a very small number of cases, the vaccine can set off a chain reaction which leads to the body confusing its own blood platelets for fragments of virus.
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen in phase 3 trials, including thrombosis with thrombocytopenia syndrome (TTS), a rare condition resembling heparin-induced thrombocytopenia (HIT), have been observed. This study demonstrates that all three adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of HIT. We have determined the structure of the ChAdOx1 viral vector and used it in state-of-the-art computational simulations to demonstrate an electrostatic interaction mechanism with PF4, which was confirmed experimentally by surface plasmon resonance. These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS.
In an exclusive and explosive one-hour interview with Veronika Kyrylenko of The New American, pioneering mRNA scientist Dr. Robert Malone explains the intensely corrupt workings of the government regulatory bodies that have mismanaged the pandemic, discusses the problems with the vaccine program and delves into potentially explosive and game-changing revelations about the shady origins of the Covid-19 pandemic in Wuhan, China.
Each line in the above table describes “vaccine effectiveness”. That is how much the vaccine REDUCES chances of illness compared to the unvaccinated. The red numbers are NEGATIVE, meaning that vaccine INCREASES chances of geting Covid, compared to the unvaccinated. For example, for vaccinated 40-49 year olds, their chances of getting covid are (see above) 2.28 TIMES HIGHER than the unvaccinated. So their vaccine is a Covid magnet. No kidding.
Over 82% of deaths in the UK are among the vaccinated.
Dr. McCullough speaks about vaccine safety, efficacy, and the continued need for early treatment.
To give you a preview of this article: Vaccines in the UK have become LESS THAN WORTHLESS in October. “The vaccinated” get infected MORE than the unvaccinated. The vaccinated have higher infection rates and are now the drivers of the UK epidemic. While some degree of “protection from death” still remains, it is dropping by about 7% every month for the most relevant groups. I break it down by age to avoid the stupid “but you need to do age adjustment” criticism, to show that the disaster is in almost every age group.
Article date: October 05, 2016
Consider this: one century ago, you couldn’t find anyone allergic to peanuts, but now it’s commonplace for parents to send EpiPens to school for the teacher and nurse to keep near to their children, just in case someone so much as opens a snack in the room that contains peanuts, or even if someone opens a food product that was so much as manufactured in “a facility that processes peanuts.” What’s wrong with the human body that it would go into anaphylactic shock from a seemingly harmless food ingredient that couldn’t harm a soul a hundred years ago? Today, peanuts cause the most common severe food allergy reactions, and are the number one cause of death from food reactions, and for good reason: Peanut oil was never meant to be put in a syringe and injected into muscle tissue.