Categories
News Opinion

Your Environment Is Cleaner. Your Immune System Has Never Been So Unprepared – New York Times (2019)

A century ago, British scientists suggested a link between increased hygiene and allergic conditions — the first hint that our immune systems are becoming improperly “trained.”

…Should you use antibacterial soap or hand sanitizers? No. Are we taking too many antibiotics? Yes.

https://web.archive.org/web/20190312120618/https://www.nytimes.com/2019/03/12/health/immune-system-allergies.html

Categories
News

Bacteria in your GUT affects your immune response to Covid-19 and could influence how severely you suffer symptoms, study finds – Dail Mail

  • South Korean study reviewed pre-existing research on role of gut microbiome  
  • Hong Kong-based scientists examined blood and stool samples from patients 
  • Both studies indicate a gut microbe imbalance is key in severe Covid-19

The study concludes the gut microbiome may be involved in the ‘magnitude of Covid-19 severity possibly via modulating host immune responses’.

The authors found that patients with Covid-19 had depleted levels of several gut bacteria known to modify a person’s immune response.

https://web.archive.org/web/20210112140105/https://www.dailymail.co.uk/sciencetech/article-9137823/Bacteria-GUT-affects-Covid-19-severity.html

Categories
Opinion Videos

Ivor Cummins on The James Delingpole Channel

Ivor Cummins aka the Fat Emperor – gives James the lowdown on why you can’t trust anything our governments tell us about Covid-19. If you want the facts on Coronavirus – how deadly is it? do lockdowns and masks work? how does it compare with previous pandemics? – you’ve come to the right place

Please support the Delingpod:

Mirror archives are available below if this video is removed from YouTube.

Categories
Opinion

Boiling the bioethical frog – The Critic

This hunger games scenario of a middle-aged, potentially pre-infected and already immune health secretary taking a nominal, rushed, improperly trialled novel-technology vaccine after the pandemic has already passed on live TV is as unethical and obscene as any of the propaganda we have been subjected to. What have we become? If it happens, the supposed vaccinator, the TV station, the secretary of state, and the vaccine company should all be roundly condemned. It proves nothing and risks everything. Obnoxious and dangerous as he is, he hasn’t a clue what might happen to him. He is still that sacred thing: somebody’s patient. A power-crazed, ignorant man for whom the mantras “whatever it takes” and the “end justifies the means” are dear, offering himself for a macabre, televised ritual sacrifice fit for the Incas to appease his political masters. It is truly grotesque. There is no medical reason for him to have these chemicals.

https://thecritic.co.uk/boiling-the-bioethical-frog/

Categories
Publications

How kids’ immune systems can evade COVID – Nature

Young children account for only a small percentage of COVID-19 infections — a trend that has puzzled scientists. Now, a growing body of evidence suggests why: kids’ immune systems seem better equipped to eliminate SARS-CoV-2 than are adults’.

“Children are very much adapted to respond — and very well equipped to respond — to new viruses,” says Donna Farber, an immunologist at Columbia University in New York City. Even when they are infected with SARS-CoV-2, children are most likely to experience mild or asymptomatic illness.

Another clue that children’s response to the virus differs from that of adults is that some children develop COVID-19 symptoms and antibodies specific to SARS-CoV-2 but never test positive for the virus on a standard RT-PCR test. In one study, three children under ten from the same family developed SARS-CoV-2 antibodies — and two of them even experienced mild symptoms — but none tested positive on RT-PCR, despite being tested 11 times over 28 days while in close contact with their parents, who had tested positive.

https://web.archive.org/web/20201211205033/https://www.nature.com/articles/d41586-020-03496-7

Categories
Videos

Dr Mike Yeadon on the UK government’s mismanagement of COVID-19 on – Unlocked

YouTube has removed interview so we have archived the video in the above location. It is currently available on Unlocked Facebook page:

https://www.facebook.com/unlockedunitedkingdom/videos/vb.112364983833705/409747283542470/

Categories
News

Quarter of people may already be immune to coronavirus – even though many have never been infected – The Telegraph

PHE researchers believe people with high levels of T-cells likely to have picked up immunity from coronaviruses like common cold

A quarter of people may already be immune to coronavirus even though many of them have never been infected, a new study by Public Health England (PHE) suggests.

https://www.telegraph.co.uk/news/2020/11/19/many-could-immune-covid-despite-never-having-infected-study/

Categories
Videos

Are We Being Told the Truth About COVID-19? – Prof. Sucharit Bhakdi, Triggernometry

Professor Bhakdi’s videos have been censored in the past. A backup mirror can be viewed below if the YouTube video is offline.

Categories
News

The Children Never Had the Coronavirus. So Why Did They Have Antibodies? – New York Times

A provocative study suggests that certain colds may leave antibodies against the new coronavirus, perhaps explaining why children are more protected than adults.

It’s been a big puzzle of the pandemic: Why are children so much less likely than adults to become infected with the new coronavirus and, if infected, less likely to become ill?

A possible reason may be that many children already have antibodies to other coronaviruses, according to researchers at the Francis Crick Institute in London. About one in five of the colds that plague children are caused by viruses in this family. Antibodies to those viruses may also block SARS-CoV-2, the new coronavirus causing the pandemic.

https://www.nytimes.com/2020/11/10/health/coronavirus-children.html

Categories
Opinion

Three facts No 10’s experts got wrong – Dr Mike Yeadon, Daily Mail

  • We have experience of SARS in 2003 and MERS in 2012, while in the UK there are at least four known strains of coronavirus which cause the common cold.
  • Many individuals who’ve been infected by other coronaviruses have immunity to closely related ones such as the Covid-19 virus.
  • Multiple research groups in Europe and the US have shown that around 30 per cent of the population was likely already immune to Covid-19 before the virus arrived – something which Sage continues to ignore.
  • Prof. John Ioannidis, professor of epidemiology at Stanford University in California, have concluded that the mortality rate is closer to 0.2 per cent – 1 in 500 infected die.
  • Around 45,000 Covid deaths in the UK
  • Approximately 22.5million people have been infected – 33.5 per cent of our population – not Sage’s 7 per cent calculation.
  • Not every infected individual produces antibodies.
  • The human immune system has several lines of defence:
    • Innate immunity which is comprised of the body’s physical barriers to infection and protective secretions (the skin and its oils, the cough reflex, tears etc);
    • Inflammatory response (to localise and minimise infection and injury), and the production of non-specific cells (phagocytes) that target an invading virus/bacterium.
    • Antibodies that protect against a specific virus or bacterium (and confer immunity) and T-cells (a type of white blood cell) that are also specific.
  • T-cells that are crucial in our body’s response to respiratory viruses such as Covid-19.
  • World Health Organisation says 750million people have been infected by the virus as of October and almost none have been reinfected.
  • Mortality in 2020 so far ranks eighth out of the last 27 years.
  • The death rate at present is also normal for the time of year – the number of respiratory deaths is actually low for late October.
  • Not only is the virus less dangerous than we are being led to believe, with almost three quarters of the population at no risk of infection.
  • I am convinced this so-called second wave of rising infections and, sadly, deaths will fizzle out without overwhelming the NHS.

https://www.dailymail.co.uk/news/article-8899053/DR-MIKE-YEADON-Three-facts-No-10s-experts-got-wrong.html

Categories
Opinion Videos

Dr. Mike Yeadon on The James Delingpole Channel

Interview highlights

  • COVID-19 is not a dread disease that will kill everyone.
  • The initially high case fatality rate of COVID-19 was because the medical community didn’t know how to treat it.
  • The fatality rate of flu is 0.1% (1 in every 1,000 who are infected end up dying).
  • Ventilators are the wrong option if you do not have an obstructed airway disease.
  • Prod. Ioannidis: The infection fatality ratio of COVID-19 is 0.15%. This is pretty much the same as the flu.
  • We should just ask people to be careful but otherwise go about your daily life.
  • These things pass every year. This is the first ‘social media pandemic.’
  • The normal practice for intensive care beds in the NHS is to run them almost full. This is because a lot of intensive care bed assignment is planned.
  • ICU use at the height of the pandemic was has very low because the NHS was run as light as possible to cope with a second wave.
  • Respiratory viruses don’t do waves.
  • This is not opinion but is basic understanding among experts in the field. It is supposrted by the highest quality science. Sir Patrick Vallance knows this.
  • COVID-19 follows the Gompertz Curve.
  • You have immunity after your body has fought off a respiratory virus. If that was not the case, you’d be dead. Immunity probably lasts decades based on evidence from other viruses.
  • Gompertz Curve is identical in all heavily infection regions.
  • Something awefull happened in the middle of the year: PCR swab test.
  • It is not true that if you test more people you’ll save more lives. A certain percentage of the test will come up positive even if there’s no virus in you.
  • False positive rate wasn’t released.
  • Kate Barker wrote in a government document on June 3rd, 2020, to SAGE: test has an unknown false positive rate; based on similar tests it may be between 1%-2%. This is a big deal.
  • Based on 1%: for every 1,000 people you test, 10 will come back positive, even if they don’t have the virus. If prevalence is only 0.1% as reported by ONS, only 1 in 1,000 will be genuine. This means 9 in 10–in other words 90%–are false.
  • Pillar 2 testing would have caused of the most of the positives to be false.
  • 1,700 people die normally every day in the UK. During the summer, only about 10 were dying per day of covid.
  • More testing, more false positives. We’ll never escape covid if we keep testing because most of the positives will be false. This is immunology 101. Sir Patrick Vallance would have known this.
  • Influenza is a high mutation-rate virus. Coronaviruses are relatively stable so once you’ve recovered, you are probably immune for decades.
  • COVID-19 kills 0.15%-0.2%, slightly more lethal than the average flu. Once it’s gone through the population, it won’t come back.
  • 99.94% survive COVID-19 and will be resistant for a long time.
  • COVID-19 is 80% similar to SARS-COV-1.
  • People who were exposed to SARS have T-cell immunity 17 years later. Evidence for COVID-19 all point in direction.
  • Our bodies have many lines of defense, including innate immunity and T-cells. Antibodies are in the last line of defense.
  • Study shows around 30% prior immunity to SARS-COV-2. It was due to exposure to common-cold coronaviruses.
  • The claim made by Sir Patrick Vallance that more than 90% are susceptible is a lie.
  • Mass testing of the well populating is the worst problem as it generates false positives, fear and control.
  • If you’re immune, you can’t be infected or infectious. Herd immunity is already in play in London.
  • If SAGE is correct, London should be ‘ablaze’ with deaths.
  • Current testing methods are not forensically sound.
  • Tests detect common cold and dead virus.
  • SARS-COV-2 has never really been a public health emergency.
  • We do not need the vaccine to return to normal. Most people are not in danger from COVID-19. More people are in danger from car crashes and we accept that risk.
  • Best case scenario is that the vaccine is 50% effective. Natural immunity might be better.
  • The most vulnerable often don’t respond well to vaccines and die anyway.
  • SAGE is giving lethally wrong advice.
  • The reason the pandemic is not over is because SAGE says it’s not.

Categories
News Opinion

Let children be exposed to viruses, says Professor Gupta – Prof. Sunetra Gupta, Evening Standard

Gupta, who is a professor of theoretical epidemiology at Oxford, told The Londoner that alongside huge social and educational benefits, the “evidence is mounting that early exposure to these various coronaviruses is what enables people to survive them”.

https://www.standard.co.uk/news/londoners-diary/the-londoner-let-children-be-exposed-to-viruses-says-professor-gupta-a4538386.html

Categories
News

We are massively overreacting to new Covid ‘outbreaks’ – The Telegraph

The Imperial College study published this morning claiming that 3.4 million people ( six per cent of the UK population) have antibodies indicating that they have been exposed to Covid-19 provides no great revelation. The Office of National Statistics (ONS) has already published similar figures suggesting that 6.5 per cent of the population has been infected. Nevertheless, it is yet more confirmation of how irrelevant are the official statistics for Covid 19 cases – and what a nonsense it is to rely on them for policymaking.

According to the Government’s Covid “dashboard”, updated at 4pm on Wednesday, 313,798 people in Britain have had the disease. This is less than one tenth of the number suggested by the Imperial study. In other words, for all Matt Hancock’s efforts to ramp up testing, the vast majority of cases have not been detected.

https://www.telegraph.co.uk/news/2020/08/13/massively-overreacting-new-covid-outbreaks/

Categories
Publications

Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2 – MedicalXpress

  • Your immune system’s ‘memory’ T cells keep track of the viruses they have seen before.
  • New study led by scientists at La Jolla Institute for Immunology (LJI) shows that memory helper T cells that recognize common cold coronaviruses also recognize matching sites on SARS-CoV-2, the virus that causes COVID-19.
  • Having a strong T cell response, or a better T cell response may give you the opportunity to mount a much quicker and stronger response.
  • 40%-60% of people never exposed to SARS-CoV-2 had T cells that reacted to the virus showing that their immune systems recognized the virus.
  • This finding turned out to be a global phenomenon and was reported in people from the Netherlands, Germany, the United Kingdom and Singapore.
  • This discovery suggests that fighting off a common cold coronavirus can induce cross-reactive T cell memory against SARS-CoV-2.

https://medicalxpress.com/news/2020-08-exposure-common-cold-coronaviruses-immune.html

Categories
Opinion

How bad is COVID really? – Sebastian Rushworth M.D.

  • Article based on experience working as a doctor in the emergency room of one of the big hospitals in Stockholm, Sweden, and of living as a citizen in Sweden.
  • Unlike other countries, Sweden never went in to complete lockdown. Non-essential businesses have remained open, people have continues to go to cafés and restaurants, children have remained in school, and very few people have bothered with face masks in public.
  • COVID hit Stockholm like a storm in mid-March. One day I was seeing people with appendicitis and kidney stones, the usual things you see in the emergency room. The next day all those patients were gone and the only thing coming in to the hospital was COVID. Practically everyone who was tested had COVID, regardless of what the presenting symptom was. People came in with a nose bleed and they had COVID. They came in with stomach pain and they had COVID.
  • Then, after a few months, all the COVID patients disappeared.
  • At the peak three months back, a hundred people were dying a day of COVID in Sweden, a country with a population of ten million. We are now down to around five people dying per day in the whole country, and that number continues to drop. Since people generally die around three weeks after infection, that means virtually no-one is getting infected any more.
  • The risk of dying is at the very most 1 in 200 if you actually do get infected.
  • In total COVID has killed under 6,000 people in a country of ten million.
  • Sweden has an annual death rate of around 100,000 people. Considering that 70% of those who have died of COVID are over 80 years old, quite a few of those 6,000 would have died this year anyway.
  • COVID will never even come close to major pandemic numbers like 1918 flu.
  • If herd immunity hasn’t developed, where are all the sick people? Why has the rate of infection dropped so precipitously?
  • The reason we test for antibodies is because it is easy and cheap. Antibodies are in fact not the body’s main defence against virus infections. T-cells are. But T-cells are harder to measure than antibodies, so we don’t really do it clinically.
  • Sweden ripped the metaphorical band-aid off quickly and got the epidemic over and done with in a short amount of time, while the rest of the world has chosen to try to peel the band-aid off slowly. 
  • I am willing to bet that the countries that have shut down completely will see rates spike when they open up. If that is the case, then there won’t have been any point in shutting down in the first place, because all those countries are going to end up with the same number of dead at the end of the day anyway. Shutting down completely in order to decrease the total number of deaths only makes sense if you are willing to stay shut down until a vaccine is available. That could take years.
  • COVID has at present killed less than 6000 in Sweden. It is very unlikely that the number of dead will go above 7,000. An average influenza year in Sweden, 700 people die of influenza. Does that mean COVID is ten times worse than influenza? No, because influenza has been around for centuries while COVID is completely new.
  • So it is quite possible, in fact likely, that the case fatality rate for COVID is the same as for influenza, or only slightly higher, and the entire difference we have seen is due to the complete lack of any immunity in the population at the start of this pandemic.

Original source: https://sebastianrushworth.com/2020/08/04/how-bad-is-covid-really-a-swedish-doctors-perspective/

Categories
Publications

Association of contact to small children with mild course of COVID-19 – medRxiv

It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection would be protective against severe course of COVID-19, it would be expected that adults with intensive and regular contact to small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4,010 recovered COVID-19 patients was conducted in Germany. 1,186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact to children below 10 years of age and 23.2% had own small children, which is higher than expected. In the relatively small subgroup with intensive care treatment (n=19), patients without contact to small children were overrepresented. These findings are not well explained by age, gender or BMI distribution of those patients and should be validated in other settings.

https://www.medrxiv.org/content/10.1101/2020.07.20.20157149v1

Categories
Opinion

Why vaccines are less effective in the elderly, and what it means for COVID-19 – The Conversation

A critical factor that makes the elderly more susceptible to infectious diseases is what immunologists call “immunosenescence”: the decline in the immune system’s functionality as people age. This is also associated with an increase in the incidence of inflammatory diseases, because an elderly body tends to be in a state of chronic low-grade inflammation. This “inflamm-aging” is one reason why older people have tendencies to develop more severe forms of respiratory diseases.

The key problem with SARS-CoV-2 infection is inflammation in the respiratory tract, which can be exacerbated in individuals predisposed towards potent inflammatory responses.

Immunosenescence also results in diminished responses to vaccination. Indeed, annual flu vaccines are notoriously less effective in the elderly. This phenomenon is very important in the context of the massive efforts and funds being invested worldwide into the ultra-rapid development of vaccines for COVID-19.

The fact that elderly people do not respond well to immunizations has largely been ignored in most discussions of COVID-19 vaccines, despite this being the group in greatest need. Most of the scientific community’s experience with vaccine development for any disease has been focused on vaccinating the relatively young.

https://web.archive.org/web/20200721234031/https://theconversation.com/why-vaccines-are-less-effective-in-the-elderly-and-what-it-means-for-covid-19-141971

Categories
Videos

Corona – The Simple Truth in Under 6 Minutes

References for the video can be found at the content creator’s website at https://the-iceberg.net

Categories
Publications

Preventing a covid-19 pandemic – BMJ

A randomized placebo-controlled trial in children showed that flu shots increased fivefold the risk of acute respiratory infections caused by a group of noninfluenza viruses, including coronaviruses. (Cowling et al, Clin Infect Dis 2012;54:1778) From Table 3, vaccine recipients had 20 noninfluenza virus-positive ARIs and 19 virus-negative ARIs; non-recipients had 3 noninfluenza virus-positive ARIs and 14 virus-negative ARIs. These figures yield an odds ratio of 4.91 (CI 1.04 to8.14).

Such an observation may seem counterintuitive, but it is possible that influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections; this has been observed with DTP and other vaccines. (Benn et al, Trends in Immunology, May 2013) There are other immune mechanisms that might also explain the observation.

https://www.bmj.com/content/368/bmj.m810/rr-0

Categories
Videos

T-cell immunity and the truth about Covid-19 in Sweden – Dr. Soo Aleman, UnHerd

“Intensive care units are getting empty, the wards are getting empty, we are really seeing a decrease — and that despite that people are really loosening up. The beaches are crowded, social distancing is not kept very well … but still the numbers are really decreasing. That means that something else is happening – we are actually getting closer to herd immunity. I can’t really see another reason.”

“I can’t say if the Swedish approach was right or wrong – I think we can say that in one or two years when we are looking back. You have to look at the mortality over the whole period.”

“I don’t think that we have more new cases, I think we are just detecting more cases”

“We found that if you have a mild case you can be negative for antibodies afterwards … in those almost all of them had strong T-cell activity. This study says that there are cases that you can have a strong T-cell response even though you have not had antibodies, meaning that you have encountered the virus and built up immunity.”