Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
Published 14 Dec 2020
Nanobiotechnology is emerging very promising to investigate novel methodologies for managing COVID-19 pandemic/endemic successfully. In this direction, experts have explored the opto-electro-magnetic nanosystem to detect the SARS-CoV-2 virus using a biosensing approach. Such optical, electrical, or magnetic biosensors function based on geno-sensing and immune-sensing has detected the SARS-CoV-2 virus selectively at a very low level. These efficient-miniaturized biosensors can be operated using a smartphone and promoted for clinical application for early-stage diagnostics of COVID-19 infection. The successful integration of these SARS-CoV-2 virus sensors with AI and IoMT enables virus detection at point-of-location and sharing of bioinformatics with the medical center at the same time for timely therapeutics decision. This approach is also useful for tracking tasks and managing COVID-19 infection according to patient infection profiling. To avoid human-to-human SARS-CoV-2 virus transmission, experts have developed stimuli-responsive nanotechnology enable which can not only trap aerosol of virus size but can eradicate viruses on applying external stimulation for example nanoenable photo-sensitive virus degradation. Various types of clothes containing nanoparticles have demonstrated SARS-CoV-2 virus trapping and eradication successfully [2,9]. However, significant attention is required to increase the production and distribution of these masks for public use.
This is not because Ted Mooney contracted coronavirus in the very good (and expensive, it must be said) care home three miles from our house, as statistics will now state.
Because he did not. Yet the principal cause of death is set down officially as Covid-19 — and that, in my view, is a bizarre and unacceptable untruth.
…They agreed that, yes, it must distort the national figures — ‘and yet the strangest thing is that every winter we record countless deaths from flu, and this winter there have been none. Not one!’
Amid the dire Covid warnings, one crucial fact has been largely ignored: Cases are down 77% over the past six weeks. If a medication slashed cases by 77%, we’d call it a miracle pill. Why is the number of cases plummeting much faster than experts predicted?
In large part because natural immunity from prior infection is far more common than can be measured by testing. Testing has been capturing only from 10% to 25% of infections, depending on when during the pandemic someone got the virus. Applying a time-weighted case capture average of 1 in 6.5 to the cumulative 28 million confirmed cases would mean about 55% of Americans have natural immunity.
…explained only by natural immunity. Behavior didn’t suddenly improve over the holidays; Americans traveled more over Christmas than they had since March. Vaccines also don’t explain the steep decline in January. Vaccination rates were low and they take weeks to kick in.
Most people infected with SARS-CoV-2 are contagious for 4–8 days.7 Specimens are generally not found to contain culture-positive (potentially contagious) virus beyond day 9 after the onset of symptoms, with most transmission occurring before day 5. This timing fits with the observed patterns of virus transmission (usually 2 days before to 5 days after symptom onset), which led public health agencies to recommend a 10-day isolation period. The short window of transmissibility contrasts with a median 22–33 days of PCR positivity (longer with severe infections and somewhat shorter among asymptomatic individuals). This suggests that 50–75% of the time an individual is PCR positive, they are likely to be post-infectious.
Despite the success of the vaccine programme, which will see all vulnerable people protected against Covid-19 in a month, it seems lockdown will largely continue until July.
Restaurants and churches possibly still closed. Travel impossible. Families forbidden to mingle indoors. The Treasury still borrowing billions to keep people on furlough. This is draining the health of our population and our economy.
Anyone would be justified in demanding to know what the past year’s sacrifices have been for, if not to end lockdown as soon as possible.
How can the Government fail to set free the country — particularly after the stellar vaccination campaign?
As with so many of the Government’s Covid-19 measures, the ten-year jail sentence is important mainly for what it tells us about the mentality of the decision-makers. Laws like these can only be justified on the footing that nothing matters except keeping infections down.
They are the work of people who think that there is no limit to the human misery, oppressive cruelty, economic damage or injustice that we must put up with if it reduces infections.
Using serum samples routinely collected in 9144 adults from a French general population-based cohort, we identified 353 participants with a positive anti-SARS-CoV-2 IgG test, among whom 13 were sampled between November 2019 and January 2020 and were confirmed by neutralizing antibodies testing. Investigations in 11 of these participants revealed experience of symptoms possibly related to a SARS-CoV-2 infection or situations at risk of potential SARS-CoV-2 exposure. This suggests early circulation of SARS-CoV-2 in Europe.
- Family said Captain Sir Tom Moore had regularly tested negative for Covid-19 until he visited hospital
- Only after a ten-day stay for pneumonia was he discharged on January 12 and then tested positive that day
- The inspirational NHS fundraiser later had to be readmitted and died in hospital surrounded by his family
- A family spokesman revealed Captain Tom’s pneumonia battle meant he had not had the coronavirus vaccine
- Centenarian became a national treasure over first coronavirus lockdown after raising millions for the NHS
- Boris Johnson today announced there would be a clap at 6pm by everyone to remember his achievements
- It came after a minute’s silence was held in the Commons by MPs in honour of the respected ex-army man
- His grandson Tom Teixeira also paid tribute to him, describing him as ‘a patriot to the country’
‘On January 22, Tom was discharged from hospital back to the family home where he felt most comfortable. Unfortunately he was left still fighting pneumonia and tested positive for Covid-19 that day.
‘Tom was able to have visitors to say goodbye to him at the end of his life. On Monday evening his daughter Hannah and grandchildren Benjie and Georgia were able to be by his side and his daughter Lucy was able to speak to him on FaceTime.’
- More than 25,000 patients caught coronavirus in hospital since second wave
- One in six Covid-19 patients in NHS hospitals in England were infected while being treated for other conditions since September
- So far this month, 5,684 Covid-positive in-patients out of 44,315 were infected after being admitted for other conditions
A specialist Covid nurse treating people at home said many of her patients had contracted the virus in hospital and were re-admitted when their conditions worsened.
The nurse said one elderly lady, originally admitted after breaking a rib in a fall, was now critically ill and had passed the virus on to two close relatives while at home.
One in five people in England may have had coronavirus, new modelling suggests, equivalent to 12.4 million people, rising to almost one in two in some areas.
It means that across the country as a whole the true number of people infected to date may be five times higher than the total number of known cases according to the government’s dashboard.
In some areas, however, the disparity may be even greater. Parts of London and the south are estimated to have had up to eight times as many cases as have been detected to date.
The analysis, by Edge Health, reveals that the true number of coronavirus infections in England could be as high as 12.4 million, equivalent to 22% of the population, as of 3 January.
Conclusions and Relevance In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission.
The number of covid-19 infections likely to have been acquired in hospital are rising again for the first time in three weeks and their proportion of all cases has reached record levels for the second wave, HSJ can reveal.
Now, evidence suggests that about one in five infected people will experience no symptoms, and they will transmit the virus to significantly fewer people than someone with symptoms. But researchers are divided about whether asymptomatic infections are acting as a ‘silent driver’ of the pandemic.
The increase in coronavirus infections appears to be slowing around the UK, latest data from the Office for National Statistics show.
Although the number of people with Covid continues to rise, the growth is levelling off.
In the week to 30 October, ONS says new daily infections in England stabilised at around 50,000.
Masks have been shown consistently over time and throughout the world to have no significant preventative impact against any known pathogenic microbes. Specifically, regarding COVID-19, we have shown in this paper that mask use is not correlated with lower death rates nor with lower positive PCR tests.
Masks have also been demonstrated historically to contribute to increased infections within the respiratory tract. We have examined the common occurrence of oral and nasal pathogens accessing deeper tissues and blood, and potential consequences of such events. We have demonstrated from the clinical and historical data cited herein, we conclude the use of face masks will contribute to far more morbidity and mortality than has occurred due to COVID-19.
- Hospital cases rose from 2,396 to 3,660 between September 30 and October 7.
- Almost one in five in hospital tested positive seven days or more after admission.
- This implies that they caught coronavirus whilst a patient there.
- The findings suggest Covid-19 hospitalisations caused by community outbreaks may not be growing as fast as some fear.
Professor Russell Viner, from University College London, demanded schools should instead remain fully open in the face of a second wave and cease their ‘flip-flopping’ between closures and openings which are ‘harming’ the education of youngsters.
He was speaking after his recently published study revealed those under 20 are 44 per cent less likely to be infected with the virus than adults.
…’We need to be thinking: “Are we testing too many children?” because of our understandable but probably unscientific and misplaced concerns about children being infected in schools.’
…it is recommended that improving vitamin D status in the general population and in particular hospitalized patients has a potential benefit in reducing the severity of morbidities and mortality associated with acquiring COVID-19.
The CDC has long maintained that the coronavirus is transmitted through droplets spread among people in close proximity to one another. On Friday, it updated its guidelines, adding that the virus also spreads through “respiratory droplets or small particles, such as those in aerosols, produced when an infected person coughs, sneezes, sings, talks, or breathes,” adding that this is the main vector of infection.
The guidance no longer says COVID-19 can be spread through the air, and the agency said it will update the language once its review process “has been completed.”