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Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts – Nature Communications

Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.

http://archive.today/2022.01.10-120437/https://www.nature.com/articles/s41467-021-27674-x

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COVID-19: T cells from common colds can protect against coronavirus infection, study finds – Sky News

People with high levels of T cells from common colds are less likely to catch COVID, according to a new peer-reviewed study.

Researchers said the findings could help provide the blueprint for the production of new vaccines which give longer-lasting immunity and would protect against current and future coronavirus variants such as Omicron and Delta.

http://archive.today/2022.01.10-095512/https://news.sky.com/story/covid-19-t-cells-from-common-colds-can-protect-against-coronavirus-infection-study-finds-12512900

Archive of study: https://evidencenotfear.com/cross-reactive-memory-t-cells-associate-with-protection-against-sars-cov-2-infection-in-covid-19-contacts-nature-communications/