Genetic match discovered in Covid’s unique furin cleavage site on spike protein
Matched genetic sequence patented by Moderna for cancer research purposes
Researchers say one in 3trillion chance Covid developed the code naturally
RESULTS Of 1050 eligible HCW, 154 and 120 were enrolled to receive BNT162b2 and mRNA1273, respectively, and compared to 426 age-matched controls. Recipients of both vaccine types had a ∼9-10-fold increase in IgG and neutralizing titers within 2 weeks of vaccination and an 8-fold increase in live Omicron VOC neutralization, restoring titers to those measured after the third vaccine dose. Breakthrough infections were common, mostly very mild, yet, with high viral loads. Vaccine efficacy against infection was 30% (95%CI:-9% to 55%) and 11% (95%CI:-43% to +43%) for BNT162b2 and mRNA1273, respectively. Local and systemic adverse reactions were reported in 80% and 40%, respectively.
CONCLUSIONS The fourth COVID-19 mRNA dose restores antibody titers to peak post-third dose titers. Low efficacy in preventing mild or asymptomatic Omicron infections and the infectious potential of breakthrough cases raise the urgency of next generation vaccine development.
One of the checks and balances on rampant bad scientific research is to continuously assess how new ideas fit into the framework of the bigger picture. A new piece of information may seem perfectly reasonable and well-documented, but the domino effect of its implications gives you another way to test its validity. When multiple lines of seemingly rock-solid evidence contradict one another, that’s a good sign that something is wrong, even if you don’t yet know why. Whenever a thread seems out of place, it’s time to pull on that thread until you can figure out what exactly is going on.
…”Trusting the science” is not (and never has been) about trusting results or trusting experts. Trusting the scientists is what got us into this mess. For science to function properly, we must NOT trust the scientists. Instead, we must trust in the messy self-correcting process that allows truth to boil to the surface even if every participant in that process is flawed.
“Science is the belief in the ignorance of the Experts”
— Richard P. Feynman
Science is the relentless competition between measurable pieces of evidence, the ruthless gauntlet of debate, the willingness to question even the most “obvious” of assumptions, and the humbleness to test and retest any and all assumptions against hard evidence, most especially when those assumptions are our own.
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
People with high levels of T cells from common colds are less likely to catch COVID, according to a new peer-reviewed study.
Researchers said the findings could help provide the blueprint for the production of new vaccines which give longer-lasting immunity and would protect against current and future coronavirus variants such as Omicron and Delta.
These data suggest that virtually all individuals with existing anti-SARS-CoV-2 CD8+ T-cell responses should recognize the Omicron VOC, and that SARS-CoV-2 has not evolved extensive T-cell escape mutations at this time.
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen in phase 3 trials, including thrombosis with thrombocytopenia syndrome (TTS), a rare condition resembling heparin-induced thrombocytopenia (HIT), have been observed. This study demonstrates that all three adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of HIT. We have determined the structure of the ChAdOx1 viral vector and used it in state-of-the-art computational simulations to demonstrate an electrostatic interaction mechanism with PF4, which was confirmed experimentally by surface plasmon resonance. These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS.
High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing.
…The US Centres for Disease Control and Prevention (CDC) identifies four of the top five counties with the highest percentage of fully vaccinated population (99.9–84.3%) as “high” transmission counties.
Conclusions As this field continues to develop, clinicians and public health practitioners should consider vaccinated persons who become infected with SARS-CoV-2 to be no less infectious than unvaccinated persons. These findings are critically important, especially in congregate settings where viral transmission can lead to large outbreaks.
Two years in, there is no doubt the Covid pandemic began in the Chinese city of Wuhan. But there is also little doubt that the bat carrying the progenitor of the virus lived somewhere else.
Central to the mystery of Covid’s origin is how a virus normally found in horseshoe bats in caves in the far south of China or south-east Asia turned up in a city a thousand miles north. New evidence suggests that part of the answer might lie in Laos.
Why haven’t lockdowns worked? There are broadly two types of respiratory virus. There are those that spread person to person – like measles – in a continuous chain of transmission, uninterrupted by season and with every susceptible contact falling ill. Then there are those we do not understand so well, like influenza, which are much more complex. Instead of the simplistic close contact model, which assumes Covid spreads like measles, we should perhaps consider an alternative more sophisticated model based on influenza. The influenza virus model is unusual – it is predicated on the majority being exposed to a particular airborne virus but, oddly, only a minority appear to be susceptible to each year’s variant. To complicate matters further, influenza can also spread person to person.
Public health officials and the medical establishment with the help of the politicized media are misleading the public with assertions that the COVID-19 shots provide greater protection than natural immunity. CDC Director Rochelle Walensky, for example, was deceptive in her October 2020 published LANCET statement that “there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection” and that “the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future.”
An antiviral surface coating technology sprayed on face masks could provide an extra layer of protection against COVID-19 and the flu.
The coating developed at The University of Queensland has already proven effective in killing the virus that causes COVID-19, and shows promise as a barrier against transmission on surfaces and face masks.
This nosocomial outbreak exemplifies the high transmissibility of the SARS-CoV-2 Delta variant among twice vaccinated and masked individuals. This suggests some waning of immunity, albeit still providing protection for individuals without comorbidities. However, a third vaccine dose may be needed, particularly in individuals with risk factors for severe COVID-19. Appropriate use of masks, especially in high-risk settings is advised.
There is a substantial overlap in pathobiology between COVID-19 and WCR exposure. The evidence presented here indicates that mechanisms involved in the clinical progression of COVID-19 could also be generated, according to experimental data, by WCR exposure. Therefore, we propose a link between adverse bioeffects of WCR exposure from wireless devices and COVID-19.
Specifically, evidence presented here supports a premise that WCR and, in particular, 5G, which involves densification of 4G, may have exacerbated the COVID-19 pandemic by weakening host immunity and increasing SARS-CoV-2 virulence by (1) causing morphologic changes in erythrocytes including echinocyte and rouleaux formation that may be contributing to hypercoagulation; (2) impairing microcirculation and reducing erythrocyte and hemoglobin levels exacerbating hypoxia; (3) amplifying immune dysfunction, including immunosuppression, autoimmunity, and hyperinflammation; (4) increasing cellular oxidative stress and the production of free radicals exacerbating vascular injury and organ damage; (5) increasing intracellular Ca2+ essential for viral entry, replication, and release, in addition to promoting pro-inflammatory pathways; and (6) worsening heart arrhythmias and cardiac disorders.
WCR exposure is a widespread, yet often neglected, environmental stressor that can produce a wide range of adverse bioeffects. For decades, independent research scientists worldwide have emphasized the health risks and cumulative damage caused by WCR. The evidence presented here is consistent with a large body of established research. Healthcare workers and policymakers should consider WCR a potentially toxic environmental stressor. Methods for reducing WCR exposure should be provided to all patients and the general population.
Professor Sucharit Bhakdi: “You are now witnessing the greatest crime that England has ever committed in its history.”
Here is statement from Dr. Malcolm Kendrick which deserves to be archived in full. Links to the to original post and archive can be found below.
Thank you to the many people who have e-mailed me recently and asked if I have been silenced. I have not. I have had letters from Public Health England and the General Medical Council, informing me that I was under investigation for daring to question anything about COVID19, particularly vaccines.
The good news is the investigations ended up nowhere, and were closed down. I have also had irate phone calls from doctors, telling me that I must not question vaccination and suchlike. This has been somewhat wearing and has caused me to remain silent for a while and think about things.
However, I do know how to play the medical regulations game. Don’t make a statement you cannot reference from a peer-reviewed journal. Don’t give direct advice to people over the internet. Provide facts, and do not make statements such as ‘vaccines are killing thousands of people.’ Or suchlike.
Not that I ever would. My self-appointed role within the COVID19 mayhem, was to search for the truth – as far as it could be found – and to attempt to provide useful information for those who wish to read my blog.
The main reason for prolonged silence, and introspection, is that I am not sure I can find the truth. I do not know if it can be found anymore. Today I am unsure what represents a fact, and what has simply been made up. A sad and scary state of affairs.
This is not just true of the mainstream and the mainstream media, which has simply decided to parrot all Government and WHO statements without any critical engagement…or thought. For example, the BBC intones that ‘In the last day, fifty people died within twenty-eight days of a positive COVID19 test…’ Or a hundred, or six. What the hell is this supposed to mean? It means nothing, it is the very definition of scientific meaninglessness.
Especially when it seems that very nearly a half of those admitted to hospital with COVID19 were not admitted to hospital with COVID19. They were admitted with something else entirely, then had a positive test whilst in hospital. In short, they were not admitted to hospital with COVID19, and almost certainly did not die of COVID19. They died with a positive COVID19 test. With, not of.
But the misinformation is equally a problem for those on the other side. Claims are made for the benefits of Ivermectin and hydroxychloroquine that simply do not stand up to scrutiny. Yes, I believe both drugs may provide some benefit, but not the claimed 90% reduction in deaths that I have seen trumpeted.
So, I have given up on COVID19. It is a complete mess, and I feel that, without being certain of the ground under my feet, I have nothing to contribute. I too am in danger of starting to make statements that are not true.
However, before leaving the area entirely, I would like to make clear some of the things I currently believe to be true, and what I do not believe to be true. If this is of any assistance to anyone. Very little is referenced, because I can very easily find a contradictory reference to any reference I provide. For each fact, there is an equal and opposite fact.
1: SARS-CoV2 exists
Many people have stated, probably correctly, that the SARS-CoV2 virus has never been fully isolated. Whatever exactly that means. Have Koch’s postulates been met? [see a bit later on] I think for viruses, Koch’s postulates are very rarely, if ever, met. Does it matter, not really.
Despite this gap I believe that SARS-CoV2 truly is a ‘new’ virus that did not exist before. So, it must have mutated somewhere, or been mutated somewhere, from another coronavirus… probably. Although it seems that SARS-CoV2 does not mutate. Instead, it creates variants which, somehow or other, is a completely different process to a mutation! I have found that language in this area means little, and words are simply twisted to suit a particular narrative.
I feel it is most likely this mutation occurred within a laboratory in Wuhan during gain of function research. But I don’t suppose we will ever know. It seems unlikely to be something that the Chinese authorities are ever going to admit… ever. As a general rule, the more fervently, and angrily, the Chinese state denies something – the more likely it is to be true.
This is a special case of a general rule that I modestly call the ‘Kendrick reverse meaning law.’ Which developed from P.G. Wodehouse’s observation that ‘When an Englishman says ‘trust me’ it is time to start counting the spoons.’
This reverse meaning was seen clearly when Matt Hancock (UK Health Secretary at the time) stated that ‘Right from the start we’ve tried to throw a ring of steel around our care homes.’ Which actually meant that ‘Right from the start we threw care homes under a bus.’ Unless, what he actually meant was that the ring of steel was put up to stop care home residents escaping. ‘Halt, who goes there….’ Sound of heavy machine gun fire, whistles screeching, attack dogs baying at the leash. ‘Go for the Zimmer frames, that should bring them down.’
2: SARS-CoV2 is generally more deadly than influenza
Of course, SARS-CoV2 is most certainly not deadlier than the influenza epidemic of 1918-19. Which is estimated to have wiped out 2% of the entire world’s population. It is probably not more deadly than the 1957 epidemic, or the 1967 influenza epidemic. But it seems more deadly than anything in the last forty years, or so. So, a bit more deadly than most influenzas that sweep through humanity every year, or so. Give or take.
Currently, SARS-CoV2 is reckoned to have killed four and half million people across the Globe. Which is 0.07% of the world’s population. However, there is an immediate problem here. With influenza, we count for one year, then start again the next year. With COVID19 we have just kept on counting, adding this year figures to last years, and so on!
Eventually, therefore, assuming COVID19 comes and goes like the flu, and we just keep on counting without end, it will end up killing a hundred million. Making it the deadliest virus ever. Far worse than any influenza? At the current rate this will take another thirty years, or so. Within one thousand six hundred and sixty-six years it will have killed everyone. Of course, there will have been a few billion replacement humans created during that time.
What is far more important is to know the infection fatality rate (IFR)? That is, what percentage of those infected with SARS-CoV2 will die? This, I am afraid, we are never going to know, as the definition of what the word ‘infected’ means has flipped this way and that and can never be pinned down.
Does it mean a positive test? Does it mean a positive test plus symptoms? [Which used to be called a ‘case’] Does it mean something else. What does infected actually mean…
Here, I defer to the Master – Lewis Carroll:
‘When I use a word,” Humpty Dumpty said in rather a scornful tone, “it means just what I choose it to mean — neither more nor less.”
“The question is,” said Alice, “whether you can make words mean so many different things.”
“The question is,” said Humpty Dumpty, “which is to be master – – that’s all.”
Accepting that no-one will define what COVID19 infection actually means, I believe the infection fatality rate is, (using previous used definitions) settling at around 0.15%. At least it was last time I looked. This was never enough to justify the panicked actions that have taken place around the globe. Never.
3: The figures make no sense – and never will
One of the central problems here, form which all other problems flow, is that the PCR (polymerase chain reaction) test is the test against which the PCR test itself is tested. We have nothing better. So, we are completely reliant on it being accurate. However, we cannot know how accurate it truly is, because there is no test against which to compare it.
I mentioned Koch’s postulates earlier. These are the tests which can prove if a ‘micro-organism’ is actually causing the disease. The ultimate gold standard:
The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms. The microorganism must be isolated from a diseased organism and grown in pure culture. The cultured microorganism should cause disease when introduced into a healthy organism. The microorganism must be re-isolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent. And good luck with all of that. The truth is that these postulates can work for bacteria, but not really for viruses. Because it is very difficult to meet them. I am not sure if they have ever been truly met for any virus.
On the matter of finding out if the virus is truly present, in anyone diagnosed with COVID19, here is a letter that was published in the BMJ in October last year
‘We are told that the virus is everywhere – in the air, in our breath, on fomites, trapped in masks – yet public health authorities seem not to be in possession of any cultivable clinical samples of the offending pathogen.
In March 2020, the World Health Organisation instructed authorities not to look for a virus but to rely instead on a genome test, the RT-PCR, which is not specific for SARS-CoV-2 (1) (2).
A Freedom of Information request to Public Health England about cultivable clinical samples or direct evidence of viral isolation has no information and refers to the proxy RT-PCR test, quoting Eurosurveillance (3).
Eurosurveillance states: “Virus detection by reverse transcription-PCR (RT-PCR) from respiratory samples is widely used to diagnose and monitor SARS-CoV-2 infection and, increasingly, to infer infectivity of an individual. However, RT-PCR does not distinguish between infectious and non-infectious virus. Propagating virus from clinical samples confirms the presence of infectious virus but is not widely available (and) requires biosafety level 3 facilities” (4).
The CDC admits that, “no quantified virus isolates of the 2019-nCoV are currently available”, and used a genetically modified human lung alveolar adenocarcinoma cell culture to, “mimic clinical specimen”(5).
It appears, therefore, that we have public health bodies without clinical samples, a test which is non-specific and does not distinguish between infectivity and non-infectivity, a requirement for biosafety level 3 facilities to even look for a virus, yet we are led to believe that it is up all our noses.
So, where is the virus?’
(5) https://www.fda.gov/media/134922/download 1
After reading this, do I still think SARS-CoV2 exists? Yes, I do. I firmly believe that I watched people dying of it, from it. They died in a way I have never seen people do so before, and I have seen a lot of people die. They seemed quite well, then suddenly their oxygen sats dropped like a stone – they still seemed okay otherwise – then they died. The end.
Very strange, and rather disturbing. I started slipping an oxygen saturation monitor onto my finger from time to time. Just in case. 99% is my average reading, if you are interested. It never dropped.
However, getting back to the testing. If you truly want to confirm the presence of a virus in a sample, you need to send it to biosafety level 3 facilities to isolate it, grow it (not really the correct word for a virus), and suchlike. This is never done in the clinical setting.
You could argue that if you wait for antibodies to develop, you can ‘prove’ that someone was infected, or not, and thus work out how accurate the PCR test has been retrospectively. Perhaps…
I speak as someone who needed seven Hepatitis B vaccinations before I produced any detectable antibodies. Did I have immunity after the first six, or not? Am I someone who simply does not make many antibodies, but still have immunity through other mechanisms? Do others simply not produce antibodies, or their level drops so fast, that they effectively disappear?
Yes, serological testing (looking for antibodies), has its own very significant problems.
‘Serological tests for SARS-CoV-2 have accuracy issues that warrant attention. They measure specific antibody responses which may take some weeks to develop after disease onset reducing the sensitivity of the assay. If blood samples were collected during the early stage of the infection, they may produce false negative results. They do not directly detect the presence of the virus. Further, antibodies may be present when SARS-CoV-2 is no longer present giving false positive case diagnosis.’ 2
In reality, we are relying on a PCR test to diagnose SARS-CoV2 infection, the accuracy of which is entirely dependent on believing that the test is accurate. Yes, that is the route to madness.
At present, in the UK, we are doing about one million tests a day 3.
We are getting about thirty thousand ‘positive’ results. Or, about 3% positive. How many of these are truly positive? Well, you can take a wild guess on that one. At one point, the CDC stated that 30% of the PCR tests were false positives. A ‘false positive’ means that test says you have the disease, when you do not. [A false negative informs you that you do not have the disease, when you do] 4.
The thirty per cent cannot be the case currently, because that would mean if you did one million tests, you would get more than three hundred thousand false positives. Instead we are getting thirty thousand, which means that it is impossible for the false positive rate to be higher than three per cent.
So, what is the true rate? Well, if is three percent, then virtually every single positive test is a false positive test. [Three per cent of one million is thirty thousand] Which would mean that no-one in the UK currently has COVID19, and everything we are doing is completely pointless. It also means that people admitted to hospital with COVID19 do not have the disease, they are suffering from, and dying from, something else with a false positive COVID19 false test stamped on their forehead.
Is it possible that no-one actually is infected with SARS-CoV2? Well, it is certainly not impossible. Here is a graph of overall mortality (risk of dying of anything) from England. These figures, unlike most others, are pretty much fully reliable. Someone is either dead, or they are not. It is a difficult thing to get wrong, or manipulate. There can be some delay in registering a death, but this is not normally a major issue.
The graph starts in last quarter 2017. As you can see, a spike in overall mortality in Spring 2020, A spike in Winter 2020/21. Currently, no excess mortality at all. So, if COVID19 is infecting hundreds of thousands of people each week, it is not showing up as any excess deaths… at all 5.
Does this mean that COVID19 has gone, and we are rushing around panicking about false positive tests? Or is it still here? Still here I think… but who knows… who knows.
This is the main reason I have given up. I just don’t know what to believe – apart from overall mortality figures. The figures are spun and massage, twisted and mangled.
Another reason why I have given up trying to make any sense of COVID19 is the enormous differences in overall mortality seen in countries that are virtually identical in life expectancy, healthcare systems, actions taken against COVID19 etc. etc.
Afters studying the figures from England, I looked at the figures from Northern Ireland.
Both countries [yes, Northern Ireland is not actually a separate country, it is part of the UK] did almost exactly the same things when it came to COVID19. They both have the National Health Service, they are as close to each other as can be – in terms of COVID19, and most other things. Here is the graph of overall morality for Northern Ireland.
Which means that something very dramatic happened in England, with regard to COVID19? Yet nothing happened in Northern Ireland. This, to me, is fascinating, although I cannot explain it. However, I know that if you were able explain why these two graphs are so weirdly different, you will be unearthing some critical truths with regard to COVID19.
Of course, no-one is remotely interested in such anomalies. Instead, they point to a country like Norway and say – ‘Look how well they did with their rapid lockdown, and preventing people crossing the border’. No-one points to Northern Ireland and says, ‘look how well they did with all their….’ All their what? All their doing exactly the same as England.
Yes, Northern Ireland does not fit with the approved narrative, so it is ignored. Anything that does not fit with the mask wearing, social isolating, vaccination will save the world narrative is simply ignored.
Or it is shouted down or censored by the self-appointed Fact-checkers. Those mighty intellects who can determine what is true, and what is not. It was thoughtful of them to descend from Mount Olympus to mingle amongst feeble minded humanity and tell us what we should, and should not, be thinking. We must all be eternally grateful that the ‘Truth Gods’ now live amongst us, to firmly inform us all what, and how, we should be thinking. And shut us down if we veer from the official narrative.
Anyway, faced with a situation where there are almost no facts that can be relied upon, from anywhere, I have officially removed myself from all discussions on the matter of COVID19.
Instead, I shall return to other areas where, whilst the truth is constantly battered and bruised, and lying in a bruised heap the corner, it is still breathing … just about alive. Sometimes it is capable of weakly raising its head and whispering quietly into my ear. I shall let you know what it says.
Vaccines typically do not outperform natural immunity, so it should come as no surprise that Covid vaccines do not offer long-term protection against infection. At the same time, we can be confident that they will continue to work well to prevent severe clinical outcomes. The role of these vaccines is to offer protection to the clinically vulnerable; to foist them upon those who are at negligible risk in the hope of augmenting herd immunity is illogical…
Will boosters achieve what two doses could not? For those who are extremely vulnerable and show no evidence of mounting a significant immune response after two doses, it is entirely reasonable to attempt a third dose.
But it can be to no-one else’s individual gain to submit to a third jab, having already reduced the risk of severe disease (which was very small in the first place for most) by receiving two inoculations. For there to be the collective benefit of herd immunity, the booster would have to provide life-long protection against infection – unless we are willing to accept repeated mass vaccination into the foreseeable future. Aside from being a colossal diversion of limited resources, that would open the door to a permanent state of lockdown as we lurch from one booster campaign to the next.
“Lockdowns,” the mass quarantine of both sick and healthy people, have never before been used for disease mitigation in the modern Western world. Previously, the strategy had been systematically ruled out by the pandemic plans of the World Health Organization (WHO) and by health experts of every developed nation. So how did we get here?
This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.