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Covid: React study finds latest wave ‘may have peaked’ in young – BBC

There are signs that the latest wave of Covid infections may have peaked in children and younger adults, according to scientists tracking the outbreak.

But rates in those older groups most vulnerable to severe disease are continuing to increase in England.

http://archive.today/2022.04.06-115735/https://www.bbc.com/news/health-61002492

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Why more and more experts say lockdown didn’t prevent people dying of Covid – and call it a ‘monumental mistake on a global scale’ – The Mail on Sunday

Speaking this week on The Mail on Sunday’s Medical Minefield podcast, Prof Woolhouse said: ‘I think that lockdown will be viewed by history as a monumental mistake on a global scale, for a number of reasons.

‘The obvious one is the immense harm the lockdown, more than any other measure, did in terms of the economy, mental health and on the wellbeing of society. 

…[A study published in Science in February 2021] also found something intriguing: lockdowns could, in a worst-case scenario, actually increase transmission of the virus by up to five per cent.

…As Dr Ali puts it: ‘Some people say lockdowns were beneficial, others that they were really terrible. 

‘The reality actually is much closer to the idea that it didn’t make much difference either way.’

For those who made painful sacrifices, that won’t be an easy truth to swallow.

https://web.archive.org/web/20220326223327/https://www.dailymail.co.uk/health/article-10655171/Englands-lockdown-did-NOT-prevent-people-dying-Covid-say-growing-number-experts.html

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Publications

4th Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC – medRxiv

RESULTS Of 1050 eligible HCW, 154 and 120 were enrolled to receive BNT162b2 and mRNA1273, respectively, and compared to 426 age-matched controls. Recipients of both vaccine types had a ∼9-10-fold increase in IgG and neutralizing titers within 2 weeks of vaccination and an 8-fold increase in live Omicron VOC neutralization, restoring titers to those measured after the third vaccine dose. Breakthrough infections were common, mostly very mild, yet, with high viral loads. Vaccine efficacy against infection was 30% (95%CI:-9% to 55%) and 11% (95%CI:-43% to +43%) for BNT162b2 and mRNA1273, respectively. Local and systemic adverse reactions were reported in 80% and 40%, respectively.

CONCLUSIONS The fourth COVID-19 mRNA dose restores antibody titers to peak post-third dose titers. Low efficacy in preventing mild or asymptomatic Omicron infections and the infectious potential of breakthrough cases raise the urgency of next generation vaccine development.

https://www.medrxiv.org/content/10.1101/2022.02.15.22270948v1.full-text

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News

Did the Covid modellers get it wrong? – The Times

It is more than a rebuke to Medley and the modellers though. This pandemic began, for many, with an announcement from Imperial College, whose study predicted 500,000 deaths if we did nothing. We locked down and never tested the prediction.

This time, in the face of what the public saw as dire predictions, we didn’t lock down and the apocalypse never came. The unspoken — and sometimes spoken — implication is clear: are we all fools?

http://archive.today/2022.02.12-105548/https://www.thetimes.co.uk/article/b7b928e6-8b4c-11ec-8600-c48a9935f856

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News

Covid 19 Omicron: South African GP who raised alarm about Omicron says she was pressured not to call it ‘mild’ – NZ Herald

The South African GP who first raised the alarm about Omicron says she was pressured by governments “not to publicly state that it was a mild illness”.

Dr Angelique Coetzee told Germany’s Die Welt newspaper this week that European governments asked her to portray the new strain as just as serious as previous Covid-19 variants, including Delta.

“I was told not to publicly state that it was a mild illness,” she said. “I have been asked to refrain from making such statements and to say that it is a serious illness. I declined.”

Asked what she meant, Coetzee said “based on the clinical picture there are no indications that we are dealing with a very serious disease”.

http://archive.today/2022.02.12-083002/https://www.nzherald.co.nz/world/covid-19-omicron-south-african-gp-who-raised-alarm-about-omicron-says-she-was-pressured-not-to-call-it-mild/XJ5H7I6E2LKVM5S655ET5HLIWI/

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Sajid Javid tells medical regulators to insist staff get jabs – The Times

Medical regulators must crack down on unvaccinated staff, the health secretary has said as he tries to deal with the fallout from abandoning compulsory jabs.

Sajid Javid has rebuked regulators and demanded that they send a “clear message” to healthcare workers that they must get a coronavirus vaccine.

http://archive.today/2022.02.08-001721/https://www.thetimes.co.uk/article/sajid-javid-tells-medical-regulators-to-insist-staff-get-jabs-q5z6wzv2f

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Number of Covid patients in ICUs plummets – The Sunday Times

A report from the Intensive Care National Audit and Research Centre suggests a collapse in the number of patients becoming very unwell. It put the number of admissions to ICU of patients with Covid at 19 on January 23. About 400 people were being admitted daily at the peak of the second wave in January last year.

http://archive.today/2022.02.06-053528/https://www.thetimes.co.uk/article/number-of-covid-patients-in-icus-plummets-rvkbl3qh2

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UK is ‘set to bin 3.5million Pfizer vaccine doses’ despite their shelf life already being extended as rollout slows – Daily Mail

Up to 3.5million Covid vaccine doses are set to be binned after reaching their expiry date, it was revealed today.

A leaked memo last month revealed that tens of millions of jabs sent to hospitals, GP surgeries and pharmacies in the run up to Christmas to fight Omicron had largely went unused.

Now NHS sources say more than half of the doses sent to some clinics are still ‘sitting in fridges’ amid falling demand for the booster shots. 

One well-placed official estimated up to 3.5m doses are likely to be binned, based on stock counts in several English regions, the Health Service Journal reports.

http://archive.today/2022.02.05-174202/https://www.dailymail.co.uk/news/article-10476167/UK-set-bin-3-5million-Pfizer-vaccine-doses-despite-shelf-life-extended.html

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News Opinion

Rejoice! An end to the dreaded Covid count… now let’s get rid of quarantine and testing too, writes GP Dr RENEE HOENDERKAMP – Daily Mail

The Government last month signalled its intention to scrap the legal requirement for infected people to self-isolate on March 24, and yesterday it was claimed that it will stop releasing daily Covid updates in April.

…The truth is that the advent of the highly infectious (although markedly milder) Omicron variant has changed everything.

Last week the Case Fatality Rate (CFR) – the proportion of infected people who died of Covid – was hovering at around 0.95 per cent.

That is way below the 15 per cent recorded when the death rate was at its peak in May 2020 when testing was minimal.

And since Monday, when the Office For National Statistics included ‘reinfections’ – people who have contracted the virus more than once – on its daily Covid dashboard for the first time, the CFR has plummeted still further.

With the addition of hundreds of thousands of cases to the weekly total, by Tuesday the CFR had fallen to 0.19 per cent, a percentage akin to that of flu, an illness which currently has a fatality rate of between 0.1 and 0.2 per cent.

The average age of death from Covid, meanwhile, remains at the pre-pandemic 82, with data from the US showing that 75 per cent of people who die with Covid have no fewer than four underlying serious conditions.

http://archive.today/2022.02.03-100712/https://www.dailymail.co.uk/debate/article-10470585/An-end-dreaded-Covid-count-lets-rid-quarantine-testing-says-NHS-GP.html

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Japan’s Kowa says ivermectin effective against Omicron in phase III trial – Reuters

Japanese trading and pharmaceutical company Kowa Co Ltd said on Monday anti-parasite drug ivermectin has been found effective for treating the Omicron variant of COVID-19 in a Phase III trial.

http://archive.today/2022.01.31-090451/https://www.reuters.com/article/health-coronavirus-japan-kowa/japans-kowa-says-ivermectin-effective-against-omicron-in-phase-iii-trial-idUSL1N2UB0AV

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Warring scientists fight on as Omicron retreats – The Sunday Times

“There are some scientists who have absolutely loved being media stars for the first time and they don’t want to stop. We don’t hear as much from the paediatricians, disease physicians, academic virologists and the immunologists who really know about these things.” (says Professor Allyson Pollock.)

Paul Hunter, professor of medicine at the University of East Anglia, said many prominent Covid voices have never written papers on infectious diseases. “It’s like me deciding, ‘I did a course on health and economics a year ago: maybe I should set up a group advising the chancellor on how to manage the tax system.’”

http://archive.today/2022.01.23-170611/https://www.thetimes.co.uk/article/warring-scientists-fight-on-as-omicron-retreats-hq2dz6kjd

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The catastrophe of the Covid models – Spiked

Everything the government has got right on Covid-19 in the past 12 months has happened when it ignored ‘the science’. If the modellers hadn’t made such fools of themselves in the summer and autumn of 2021 they might have been taken more seriously by the government in the winter. As it was, their incompetence had seeded enough doubt in Johnson’s mind for him to resist going beyond ‘Plan B’ despite almost every ‘scenario’ modelled telling him that hospitalisations and deaths from the virus would exceed anything England had ever seen before.

https://web.archive.org/web/20220121140042/https://www.spiked-online.com/2022/01/21/the-catastrophe-of-the-covid-models/

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Opinion

I’m a doctor and this is why we MUST start treating Covid like flu – Dr. Charles Levinson, Mail Plus

We need to start living with this virus before it wrecks even more young people’s lives, further devastates the economy and continues to pour fuel on the fire of the non-Covid health crisis.

Don’t get me wrong – flu is no joke. Familiarity has meant people assume it’s a runny nose or feeling under the weather, but it’s not.

A bad flu year produces a significant death toll. In the 2017/18 winter, 22,087 flu-associated deaths were recorded in England. The year before it was 15,047. These are over a few months only, so the daily death rate is very high. Those numbers could also be an underestimate as testing for flu is minuscule compared with our Covid effort. 

http://archive.today/2022.01.20-145519/https://www.mailplus.co.uk/edition/health/medical-matters/146470/why-we-must-start-treating-covid-like-flu

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High Covid death rates skewed by people who died from other causes, admits Sajid Javid – The Telegraph

Daily reported Covid death figures are too high because people are dying from conditions unrelated to the virus after testing positive, Sajid Javid has admitted.

On Wednesday, there were 359 deaths reported in Britain, but the Health Secretary said that “many” people were being included in the count who “would not have necessarily died of Covid”.

His comments came after death data from the Office for National Statistics (ONS) show a large discrepancy in weekly death registrations compared to the figures released on the Government dashboard.

For the week ending Jan 7, the UK Health Security Agency reported 1,282 deaths of people who had died within 28 days of testing positive for coronavirus.

However, ONS data show there were just 992 death registrations with Covid mentioned on the death certificate in that week.

http://archive.today/2022.01.20-173140/https://www.telegraph.co.uk/politics/2022/01/19/high-covid-death-rates-include-people-did-not-die-virus-admits/

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A QUARTER of all Covid ‘deaths’ are now patients who died WITH the virus not from it, official data shows – Daily Mail

Covid was not the underlying cause of death in nearly a quarter of virus-related fatalities last week, official figures suggest.

The most up-to-date Office for National Statistics figures showed there were 922 deaths registered in England and Wales mentioned coronavirus on the death certificate in the week to January 7. Of them, Covid was not ruled to be the primary reason for the death in 210 cases, or 23 per cent — although it may have been a contributing factor. 

For comparison, the share of deaths not primarily due to the virus stood at around 16 per cent when Omicron first arrived in the UK. With the Alpha wave last January, before the country embarked on its historic vaccination drive, the proportion was about 10 per cent.

The rise of the milder strain has led to a similar pattern emerging in hospitals, where nearly half of virus inpatients are not primarily needing treatment for the infection — compared to about 25 per cent with Delta. 

http://archive.today/2022.01.18-162511/https://www.dailymail.co.uk/news/article-10413701/A-QUARTER-Covid-deaths-patients-died-virus.html

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Covid outbreaks now shrinking in 96% of England’s neighbourhoods: Maps show how Omicron is fizzling out naturally and graphs lay bare how SIX TIMES fewer deaths happened in third wave despite cases being triple level of last winter – Daily Mail

EXCLUSIVE: UKHSA data shows infections are dropping in 96% of the country’s nearly 7,000 neighbourhoods

Parts of Castle Point, Shropshire and Bexley have seen infections fall by more than 70% week-on-week

And MailOnline analysis shows Omicron wave deaths were seven times lower than the peak last winter 

Official figures show half as many Covid patients were in hospital at one time compared to the Alpha peak

And 4.5 times fewer patients were moved to critical care beds during the latest wave compared to last winter 

Coronavirus cases are now falling in virtually every area of England, official figures show as the Omicron wave continues to collapse with deaths six times lower than in the second wave.

Some 6,519 out of 6,790 neighbourhoods (96 per cent) around the country recorded a fall in infections in the week to January 11, according to the UK Health Security Agency (UKHSA). 

http://archive.today/2022.01.17-152417/https://www.dailymail.co.uk/news/article-10410053/Covid-outbreaks-shrinking-96-Englands-neighbourhoods.html

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News

The C.D.C. concedes that cloth masks do not protect against the virus as effectively as other masks – The New York Times

The Centers for Disease Control and Prevention on Friday clarified its stance on various kinds of masks, acknowledging that the cloth masks frequently worn by Americans do not offer as much protection as surgical masks or respirators.

While this disparity is widely known to the general public, the update marks the first time the C.D.C. has explicitly addressed the differences. The agency’s website also no longer refers to a shortage of respirators.

The change comes as infections with the highly contagious Omicron variant continue to soar. Some experts have said that cloth masks are inadequate to protect from the variant, and have urged the C.D.C. to recommend respirators for ordinary citizens.

http://archive.today/2022.01.17-035141/https://www.nytimes.com/2022/01/14/health/cloth-masks-covid-cdc.html

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Publications

Ocado cuts sick pay for unvaccinated staff – Grocery Gazette

Ocado has announced it is cutting sick pay for unvaccinated staff who must self-isolate due to exposure to Covid-19.

According to the BBC, the online grocer will continue to offer full sick pay if unvaccinated workers test positive for the virus but will reduce sick pay for exposure related isolation.

http://archive.today/2022.01.17-172326/https://www.grocerygazette.co.uk/2022/01/14/ocado-cuts-sick-pay-for-unvaccinated-staff/

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New COVID-19 vaccine that covers Omicron ‘will be ready in March,’ Pfizer CEO says – Yahoo! Finance

Two doses of Pfizer vaccine offer limited protection, says Albert Bourla, Pfizer CEO.

http://archive.today/2022.01.12-130729/https://uk.finance.yahoo.com/video/covid-19-vaccine-covers-omicron-144553437.html

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Publications

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts – Nature Communications

Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.

http://archive.today/2022.01.10-120437/https://www.nature.com/articles/s41467-021-27674-x