Antibodies

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Publications

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis – American Heart Association

RESULTS:
Extensive antibody profiling and T-cell responses in the individuals who developed postvaccine myocarditis were essentially indistinguishable from those of vaccinated control subjects, despite a modest increase in cytokine production. A notable finding was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL), unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired t test; P<0.0001).

CONCLUSIONS:
Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine–induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.

Commentary from Wall Street Journal Article: ‘Experts’ Are Fueling Distrust in Vaccines

An article in the American Heart Association’s journal Circulation last week found a link between myocarditis in teens and higher circulating levels of vaccine spike proteins in the blood. The authors found no correlation with vaccine antibody or T-cell responses, suspected by many as the cause of myocarditis.

http://archive.today/2023.01.11-010228/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.061025

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Publications

Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination – Science

RNA vaccines are efficient preventive measures to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7–18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9–2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.

http://archive.today/2023.01.02-215315/https://www.science.org/doi/10.1126/sciimmunol.ade2798

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Videos

Dr Peter McCullough with Joe Rogan – The Joe Rogan Experience 1747

Dr. Peter A. McCullough, MD, MPH, is a board-certified cardiologist who has testified before committees of the US and Texas Senate regarding the treatment of COVID-19 and management of the ongoing pandemic.

Backup mirrors:

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Opinion

110 Research Studies Affirm Naturally Acquired Immunity to Covid-19: Documented, Linked, and Quoted – The Brownstone Institute

Public health officials and the medical establishment with the help of the politicized media are misleading the public with assertions that the COVID-19 shots provide greater protection than natural immunity.  CDC Director Rochelle Walensky, for example, was deceptive in her October 2020 published LANCET statement that “there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection” and that “the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future.” 

https://brownstone.org/articles/79-research-studies-affirm-naturally-acquired-immunity-to-covid-19-documented-linked-and-quoted/
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Videos

Meeting of the COVID-19 Giants with Geert Vanden Bossche and Robert Malone MD

Dr. Philip McMillan interviews vaccine developer Geert Vanden Bossche and Robert Malone MD, inventor of mRNA vaccine platform.

https://youtu.be/qP31cfD3YOY

Interview highlights

  • Geert Vanden Bossche (GV) at 17m: Massive surges of the infection rates, especially in countries with an aggressive mass-vaccination policy, was predictable.
  • Robert Malone (RM) at 23m: The Israeli data is a concern: we are seeing signs that the durability of the [Pfizer vaccine] is very poor.
  • RM at 26m: The vaccinated are a higher risk of becoming superspreaders because they’re replicating virus at the same or higher levels than the unvaccinated but they feel better.
  • GV at 28m: The effect of mass-vaccination is an ideal breeding-ground for more infections spread. However, if still have a substantial proportion that is non-vaccinated, you will see a reduction of infectious pressure.
  • GV at 31m: The unvaccinated are ‘the vaccum cleaners’ who will eliminate a lot of virus from the population by mounting long-lived immunity and contribute to the reduction of infectious pressure. The vaccinated cannot contribute to the infectious pressure.
  • RM at 33m: The truth is that it’s the vaccinated that are creating the risk, not the unvaccinated. The unvaccinated are serving as virus sinks. The probability of them having significant disease and death is minute. The real risk is the vaccinated who have received very focused spike proteins.
  • GV at 35m: It is not a problem of individuals being vaccinated. The problem is a policy of mass-vaccination. That is how the more infections variant can adapt to the population and become dominant.
  • GV at 58m: Young people are now getting the disease pretty fast because of the increased infectious pressure [due to mass-vaccination].
  • RM at 1h10m: There are disincentives to asking questions about data for vaccine-enhanced replication and antibody-dependent enhancement; no-one wants fund the studies.
  • GV at 1h12m: Regulators have no experience with the current situation where there are very many unknowns when deploying a new vaccine to the public.
  • RM at 1h17m: The FDA is not structured to detect adverse advents and have admitted they cannot evaluate safety. Two of the top [US] regulators resigned because the FDA is no longer independent from the policy-making apparatus which exists in the Executive Branch [of US Government].
  • RM at 1h24m: There is an intrinsic conflict of interest in the CDC in that it is funded to promote vaccines but also has the under-funded mission of evaluating their safety.
  • RM at 1h25m: Policy recommendations together with Peter Navarro (American economist and author):
    • Reserve vaccines for the high-risk population and make it available globally.
    • Make early interventions [like Ivermectin and Vitamin D] widely available. Many are very effective when administered early and aggressively.
    • Make home-test kits available (acknowledging that they have a bias to false positives) and make more specific tests in physicians offices.
    • Address the fear by showing that currently most people are not at risk.
  • GV at 1h30m: The most important thing is to reduce the infectious pressure. This is a huge threat to all those who were naturally protected, such as young people. The worst thing to do is to vaccinate the younger age groups because they are ‘the buffer’ of long-lived immunity. They are our hope for herd immunity. We will not get herd immunity from mass-vaccination.
  • GV at 1h39m: We need to compare the ratio of severe disease of deaths in vaccinated and unvaccinated. We are seeing more case fatalities in the vaccinated but the numbers are not being made available.
  • RM at 1h41m: There is a persistent signal in the UK data that there seems to be an excess deaths in the vaccinated and yet a relative deficit in the vaccinated. This is paradoxical.
  • GV at 1h47m: Discrimination against the non-vaccinated is complete scientific nonsense. We should care about susceptibility. What is relevant is how can we protect ourselves best.

Slides:

Backup mirrors:

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News

Is catching Covid now better than more vaccine?

“We could be digging ourselves into a hole, for a very long time, where we think we can only keep Covid away by boosting every year,” Prof Eleanor Riley, an immunologist from the University of Edinburgh, told me.

Prof Adam Finn, a government vaccine adviser, said over-vaccinating people, when other parts of the world had none, was “a bit insane, it’s not just inequitable, it’s stupid”.

http://archive.today/2021.08.21-104255/https://www.bbc.com/news/health-58270098

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Videos

Proof that puts an end to the Sars-CoV-2 Narrative – Professor Sucharit Bhakdi, Oracle Films

Some good news and some troubling news, from Professor Sucharit Bhakdi, M.D.

Oracle Films recently produced an interview with Professor Sucharit Bhakdi in collaboration with Oval Media in Germany, for an upcoming documentary.

As an aside to the interview, Dr. Bhakdi emphasised the urgent need to share the following information that has emerged from new scientific literature.

PLEASE take the time to process this presentation. Dr. Bhakdi explains clearly, based on new scientific evidence, why he believes:

* Your immune system is your best defence against SARS-CoV-2, and indeed all coronaviruses. If you have been infected, even if you experienced no symptoms at all, you are immune to all variants.
* We have already reached herd immunity.
* There is no scientific reason to vaccinate against SARS-CoV-2. There is simply no benefit and the rollout must be stopped.

Scientific literature references for Dr. Bhakdi’s presentation:

Update: On 17 July 2021, Dr. Geert Vanden Bossche posted a response to Dr. Bhakdi’s conclusions. Both agree that mass vaccination should halt but differ on the dangers of variants and whether herd immunity has been reached.

Source: https://www.geertvandenbossche.org/post/response-to-dr-bhakdi
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News

Common colds could prime the immune system to fight off Covid – The Telegraph

Common colds may prime the immune system against Covid, scientists believe, after finding that some people never develop an infection despite repeated exposure to the virus.

Researchers at University College London (UCL) have discovered that some people have natural protection against Covid and seem to fight off an infection using pre-existing memory T-cells.

https://www.telegraph.co.uk/news/2021/07/02/common-colds-could-prime-immune-system-fight-covid/

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Publications

SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity – Science Direct

We report broad serological profiles within the cohort, detecting antibody binding to other human coronaviruses. 202(>99%) participants had SARS-CoV-2 specific antibodies, with SARS-CoV-2 neutralization and spike-ACE2 receptor interaction blocking observed in 193(95%) individuals. A significant positive correlation (r=0.7804) between spike-ACE2 blocking antibody titers and neutralization potency was observed. Further, SARS-CoV-2 specific CD8+ T-cell responses were clear and quantifiable in 95 of 106(90%) HLA-A2+ individuals.

https://www.sciencedirect.com/science/article/pii/S2352396421002036

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Publications

Human IgG and IgA responses to COVID-19 mRNA vaccines – PLOS ONE

SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7–10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<18% peak levels within 100 days of the 2nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249499

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Manipulative magnetic nanomedicine: the future of COVID-19 pandemic/endemic therapy – Taylor & Francis Online

Published 14 Dec 2020

Nanobiotechnology is emerging very promising to investigate novel methodologies for managing COVID-19 pandemic/endemic successfully. In this direction, experts have explored the opto-electro-magnetic nanosystem to detect the SARS-CoV-2 virus using a biosensing approach. Such optical, electrical, or magnetic biosensors function based on geno-sensing and immune-sensing has detected the SARS-CoV-2 virus selectively at a very low level. These efficient-miniaturized biosensors can be operated using a smartphone and promoted for clinical application for early-stage diagnostics of COVID-19 infection. The successful integration of these SARS-CoV-2 virus sensors with AI and IoMT enables virus detection at point-of-location and sharing of bioinformatics with the medical center at the same time for timely therapeutics decision. This approach is also useful for tracking tasks and managing COVID-19 infection according to patient infection profiling. To avoid human-to-human SARS-CoV-2 virus transmission, experts have developed stimuli-responsive nanotechnology enable which can not only trap aerosol of virus size but can eradicate viruses on applying external stimulation for example nanoenable photo-sensitive virus degradation. Various types of clothes containing nanoparticles have demonstrated SARS-CoV-2 virus trapping and eradication successfully [2,9]. However, significant attention is required to increase the production and distribution of these masks for public use.

https://www.tandfonline.com/doi/full/10.1080/17425247.2021.1860938

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Publications

Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant first discovered in India – The Francis Crick Institute

Levels of antibodies in the blood of vaccinated people that are able to recognise and fight the new SARS-CoV-2 Delta variant first discovered in India (B.1.617.2) are on average lower than those against previously circulating variants in the UK, according to new laboratory data from the Francis Crick Institute and the National Institute for Health Research (NIHR) UCLH Biomedical Research Centre, published today (Thursday) as a Research letter in The Lancet.

The results also show that levels of these antibodies are lower with increasing age and that levels decline over time, providing additional evidence in support of plans to deliver a vaccination boost to vulnerable people in the Autumn. 

https://www.crick.ac.uk/news/2021-06-03_pfizer-biontech-vaccine-recipients-have-lower-antibody-levels-targeting-the-delta-variant-first-discovered-in-india

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Publications

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination – The Lancet

In the case of single-dose recipients, our data show that NAbTs are significantly lower against B.1.617.2 and B.1.351 VOCs relative to B.1.1.7, implying that although a single dose might still afford considerably more protection than no vaccination, single-dose recipients are likely to be less protected against these SARS-CoV-2 variants. These data therefore suggest that the benefits of delaying the second dose, in terms of wider population coverage and increased individual NAbTs after the second dose,7 must now be weighed against decreased efficacy in the short-term, in the context of the spread of B.1.617.2. Worldwide, our data highlight the ongoing need to increase vaccine supply to allow all countries to extend second-dose protection as quickly as possible.

In the longer term, we note that both increased age and time since the second dose of BNT162b2 significantly correlate with decreased NAb activity against B.1.617.2 and B.1.351—both of which are also characteristic of the population in the UK at highest risk of severe COVID-19 (ie, older and vaccinated earlier), independent of other existing factors such as compromised immune status or comorbidity, or geographic-specific responses to vaccination.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01290-3/fulltext

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Publications

Had COVID? You’ll probably make antibodies for a lifetime – Nature

People who recover from mild COVID-19 have bone-marrow cells that can churn out antibodies for decades, although viral variants could dampen some of the protection they offer.

Many people who have been infected with SARS-CoV-2 will probably make antibodies against the virus for most of their lives. So suggest researchers who have identified long-lived antibody-producing cells in the bone marrow of people who have recovered from COVID-19.

https://www.nature.com/articles/d41586-021-01442-9

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News

How the vaccine can make Covid worse – Conservative Woman

EVIDENCE is growing that Covid-19 vaccines may worsen the disease in some recipients. The danger arises when a vaccinated person meets the actual virus. Antibodies developed as a result of the jab can end up enhancing disease rather than protecting against infection.

Previous warnings about this potentially lethal effect, known as antibody-dependent enhancement (ADE), have been downplayed or dismissed as theoretical by the manufacturers. The phenomenon has been seen with vaccines against other viruses but is considered very rare.

After reviewing published evidence concerning the effect, however, two US experts [1] have concluded it is ‘non-theoretical and compelling’. Receiving the vaccine could convert a subject from someone who experiences mild disease ‘to someone who experiences severe disease, lasting morbidity or even death’. 

https://www.conservativewoman.co.uk/how-the-vaccine-can-make-covid-worse/

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Videos

Professor Dolores Cahill says that mRNA vaccines enhances the illness and the disease – Asia Pacific Today

Citizens subjected to punitive restrictions on their liberties and movement for more than 12 months, are now being forced into mass, and what will soon be, mandatory vaccination programs to gain back their freedoms. Political leaders continue use the vacuous and dishonest slogan of “following the science” that many still believe, but are they leading us into another form of hell?

The Covid-19 vaccines are new vaccines and only provisionally approved. They are still in the trial phase which ends at earliest in 2023. Brilliant they may well be, and enormously enriching for their investors, but are our Government’s providing the facts for informed choice in vaccination? Are there other risks to their rushed vaccine rollouts, including to front line medical and essential service workers? And why are so many eminent scientists and influential community leaders in our countries being silenced by social and mainstream media?

The Victorian Government recently commissioned a paper entitled Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies. We are not hopeful but will attempt to discuss the paper with one of its authors in another episode.

In the meantime, to talk about mRNA vaccines and Antibody Dependent Enhancement is Professor Dolores Cahill, a renown expert in immunology and the study of immune systems.

Dr. Cahill is a Professor of University College Dublin and was Group Leader of the Max-Planck-Institute in Berlin, Germany from 1995 to 2003. She is an Inventor, Founder and Shareholder of companies and has international Patents with applications for improving the early diagnosis of diseases such as auto immune diseases & cancer.

Dr. Cahill has been an Expert in the EU for some 15 years in Future & Emerging technologies. Professor Cahill’s latest business ventures include the World Freedom Alliance, a worldwide platform of organisations offering access to justice, true dialogue for health science and politics, holding worldwide officials to account under the law. The World Freedom Alliance offers transparent evidence-based solutions and encourages robust debate with media, scientists and governments to ensure fundamental freedoms for people of the world.

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News

How did Sage get it so wrong? – The Spectator

Professor Neil Ferguson struck an unusually optimistic tone this week. With just one Covid death reported on Monday, and infection levels at an eight-month low in the UK, the architect of the original lockdown said: ‘The data is very encouraging and very much in line with what we expected.’ The first half of that statement is certainly true; the second half much less so.

https://www.spectator.co.uk/article/How-did-Sage-get-it-so-wrong

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Opinion Videos

Covid is the cure worse than the disease? Dr John Lee, Unlocked

Unlocked Exclusive — in a hard-hitting interview, retired NHS pathologist Dr John Lee discusses the government’s response to the pandemic, analyses why proven scientific procedures were abandoned, makes the case for ending Lockdown now, and asks the question most doctors are unable to discuss in public. Covid-19: is the cure worse than the disease?

Backup mirrors:

https://www.facebook.com/unlockedunitedkingdom/videos/506787697359395/

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Opinion

We’ll Have Herd Immunity by April – Wall Street Journal

Amid the dire Covid warnings, one crucial fact has been largely ignored: Cases are down 77% over the past six weeks. If a medication slashed cases by 77%, we’d call it a miracle pill. Why is the number of cases plummeting much faster than experts predicted?

In large part because natural immunity from prior infection is far more common than can be measured by testing. Testing has been capturing only from 10% to 25% of infections, depending on when during the pandemic someone got the virus. Applying a time-weighted case capture average of 1 in 6.5 to the cumulative 28 million confirmed cases would mean about 55% of Americans have natural immunity.

…explained only by natural immunity. Behavior didn’t suddenly improve over the holidays; Americans traveled more over Christmas than they had since March. Vaccines also don’t explain the steep decline in January. Vaccination rates were low and they take weeks to kick in.

https://www.wsj.com/articles/well-have-herd-immunity-by-april-11613669731

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News

Why did COVID fail to take off in India and has now collapsed? Mystery plunge in coronavirus baffles experts – Daily Mail

Scientists are trying to work out why coronavirus cases in India are falling when at one point it looked like the country might overtake the US as the worst-hit nation.

In September the country was reporting some 100,00 new cases per day, but that went into decline in October and is now sitting at around 10,000 per day – leaving experts struggling to explain why.

While the Indian government has been keen to put the apparent success down to its mask-wearing and social distancing laws, few believe these measures alone are responsible for the dip.

Instead, experts believe it may be down to the fact that India’s largest cities have reached herd immunity, meaning the virus has moved to rural areas where it spreads slower and where cases and deaths are far less likely to be tested and logged. 

https://www.accuweather.com/en/gb/kensington/w8-7/minute-weather-forecast/323272