Mexican health officials are investigating after two babies died and 29 children were hospitalized from suspected adverse reactions to shots from the country’s national vaccination program.
Six of the children hospitalized in the southern Mexican state of Chiapas remain in serious condition, the Mexican Social Security Institute said on Sunday.
The illnesses were reported after 52 children from the rural mining community of La Pimienta were given vaccines Friday for tuberculosis, rotavirus and Hepatitis B, the institute said. Later that night, 31 of the children “presented adverse reactions presumably associated with the application of these vaccines,” officials said. Two of the children later died.
We compared the results of an antigen test (ELISA) with those of polymerase chain reaction (PCR) for the detection of rotavirus and norovirus in stool specimens. Rotavirus and norovirus antigen-positive stool specimens were collected, and rotavirus and norovirus PCRs were performed on these specimens. Of the 325 rotavirus antigen-positive specimens, 200 were positive for both assays and 125 were PCR negative. Of 286 norovirus antigen-positive specimens, 51 were PCR negative. Comparison of the lower limit of detection showed that rotavirus PCR was 16 times more sensitive and norovirus PCR was over 4,000 times more sensitive than the ELISA. Discrepant results between ELISA and PCR were common, and the possibility of false-positive and false-negative results should be considered with rotavirus and norovirus assays.